Chemical Probes in Biology

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Format: Paperback
Pub. Date: 2003-12-01
Publisher(s): Kluwer Academic Pub
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Summary

The field of Bio-organic Chemistry or Chemical Biology, as it it also called, constitutes a highly interdisciplinary branch of chemistry, beyond the traditional pathways in which chemists and biologists have been working in the past. The topics covered in this book include inter alia: anticancer agents, antioxidants, chemotaxis, carbohydrates, DNA detection and delivery, enzyme structure, enzyme assisted syntheses, fluorescent probes, gene therapy, genomics, inositol phospholipids, inositol phosphates, multivalent ligands, organic syntheses, oxidative stress, photoaffinity labeling techniques, natural products - syntheses and biological activities, phospholipases, proteomics, receptors such as tyrosine kinases, signal transduction phenomena, x-ray crystallography and many more. The book represents an excellent survey of the current stete of the art in an exciting area of interdisciplinary science and supplies an incentive for increased cooperation in Science at the Interface of Chemistry, Biology and Medicine.

Table of Contents

Preface ix
Nitric Oxide: A Simple Free Radical With Complex Chemistry And Biology
1(20)
Jason P. Eiserich
Glycopeptides And Glycoproteins: Synthetic Chemistry And Biology
21(14)
Oliver Seitz
Signal Regulated Gene Expression Mediated By Transcription Factors-Members Of AP-1 And ETS/SRF Family Members: Pathways For Potential Therapeutic Intervention
35(4)
Alex Pintzas
Biological Activities Of The Phosphoinositide Derivatives, The Glycerophosphoinositols
39(12)
Stefania Mariggio'
Beatrice Maria Filippi
Cristiano Iurisci
Daniela Corda
Chemical Synthesis Of All Naturally Occurring Phosphorylated Inositol Phospholipids
51(12)
Karol S. Bruzik
Molecules Of The Inositol Phospholipid Pathway - Enzyme Assisted Syntheses
63(20)
P. Andersch
M. Berger
B. Jakob
K. Lange
M. P. Schneider
Phosphatidylinositol Specific Phospholipases C: Structure And Mechanism Of Action
83(10)
Karol S. Bruzik
Epidermal Growth Factor Receptor Signal Trans-Activation
93(12)
Stefan Hart
Andreas Gschwind
Andreas Roidl
Axel Ullrich
From Sequence To Consequence: Structural Biology And Rational Drug Design In The Age Of Genomics
105(16)
Gregory A. Petsko
Dagmar Ringe
Leukocyte-Derived Myeloperoxidase Is A Physiological Nitric Oxide And Nitrite Oxidase: Functions Beyond Host Defense
121(16)
Jason P. Eiserich
Lipoic Acid, A Metabolic Antioxidant Stimulates The Insulin Signaling Pathway In Adipocytes And Counteracts Oxidative Stress And Age Related Mitochondrial And Cognitive Dysfunction
137(8)
Lester Packer
Lipid Peroxidation And Oxidative Stress Induced Etheno- DNA Adducts In Humans And Rodents
145(8)
J. Nair
H. Bartsch
Brassinosteroids: A New Role Of Steroids As Bio-Signaling Molecules
153(14)
Vladimir Khripach
Vladimir Zhabinskii
Raisa Karnachuk
Dopamine Influence On Glutamatergic And GABAergic Interaction In Neocortex Of Awaked Brain
167(14)
V.M. Storozhuk
Study Of Human Replication Protein A By Photoaffinity Labeling Technique
181(12)
O.I. Lavrik
P.E. Pestryakov
J.K. Nazarkina
S.N. Khodyreva
Photoaffinity Probes In Molecular Biology Of DNA Replication And DNA Repair
193(14)
O.I. Lavrik
S.N. Khodyreva
Neoglycoconjugates As Probes In Glycobiology
207(20)
N. V. Bovin
Glycosylphosphatidylinositol Anchors
227(8)
L.M. Thomson
T. Fontaine
A. Mehlert
M.A.J. Ferguson
Development Of New Synthetic Tools For The Preparation Of Biologically Active Molecules
235(10)
Steven V. Ley
Ian R. Baxendale
Peter Grice
Quaternary Benzo[C]Phenanthridine Alkaloids-Biological Activities
245(10)
V. Simanek
R. Vespalec
A. Sedo
J. Ulrichova
J. Vicar
The Fundamental Role Of Melanocortins In Brain Processes
255(14)
V. Klusa
B. Jansone
S. Svirskis
J. Rumaks
R. Muceniece
Carbon Isotope Effects As A Tool To Study Photosynthesis
269(18)
Alexander A. Ivlev
Homogeneous DNA Detection
287(10)
Oliver Seitz
Unlocking Mechanisms In Gene Therapy, Stress And Proteomics
297(20)
Andrew D. Miller
Cationic Lipid-Nucleic Acid Complexes (Lipoplexes): From Physicochemical Properties To In Vitro And In Vivo Transfection Kits
317(28)
Dmitri Simberg
Danielle Hirsch-Lerner
Nicolaas-Jan Zuidam
Simcha Even-Chen
Miryam Kerner
Hagit Eliyahu
Natalie Servel
Sarah Weisman Alla Plis-Finarov
Yeshayahu Talmon
Yechezkel Barenholz
Multivalency In Biological Systems
345(14)
L.L. Kiessling
A.C. Lamanna
Protein Assembly To Mine The Human Genome
359(12)
Bradley L. Nilsson
Matthew B. Soellner
Ronald T. Raines
Synthesis Of Biologically Important Oligosaccharides And Carbohydrate Mimics
371(8)
Pierre Sinay
Enzymatic Synthesis Of Carbohydrate Ligands For Natural Killer Cells
379(12)
Vladimir Kren
From Tyrphostins to Iressa and Gleevec: Signal Transduction Therapy From Concept To The Patient Bed
391
Alexander Levitzki
Dina Ben- Yehudah

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