Metastasis of Prostate Cancer

by Ablin, Richard J.; Mason, Malcolm D.
Edition: 1st
Format: Hardcover
Pub. Date: 2007-08-03
Publisher(s): Springer Verlag
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Summary

This volume brings together the key research issues in clinical and laboratory science relating to metastasis in prostate cancer. It is especially suitable for those in the field, whether physicians and/or scientists, and whether in active research or in training, who wish to broaden their understanding, with regard to their own discipline, and also to another. It is also a resource for those whose research is in metastasis, but in diseases other than prostate cancer. The intention of this volume is to help to empower those who seek to further exploit the potential for translational research in this field. Written by a team of internationally recognised experts, the scope ranges from the most fundamental aspects of the molecular biology of metastasis, to the patient in the clinic. The therapeutic approaches range from conventional drug design to immunogene therapy. Prostate cancer is an area of intense research effort, and this book provides a window on contemporary research in this important area.

Table of Contents

List of Contributorsp. ix
Introduction: Metastasis as a Therapeutic Targetp. 1
The Natural History of Prostate Cancerp. 5
The Search for Genes Which Influence Prostate Cancer Metastasis: A Moving Target?p. 21
Polyunsaturated Fatty Acids and Prostate Cancer Metastasisp. 63
Role of Prostaglandin Synthesis and Cyclooxygenase-2 in Prostate Cancer and Metastasisp. 87
Cell Cycle Regulationp. 111
Epithelial-Mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticityp. 127
Orthotopic Metastatic Mouse Models of Prostate Cancerp. 143
ß-Catenin, its Binding Partners and Signalling Mechanisms: Implications in Prostate Cancerp. 171
Hepatocyte Growth Factor/Scatter Factor and Prostate Cancer Metastasisp. 197
Matrix Degradation in Prostate Cancerp. 221
The Biology of Bone Metastases from Prostate Cancer and the Role of Bisphosphonatesp. 253
Hormone Therapy for Prostate Cancerp. 283
Strategies for the Implementation of Chemotherapy and Radiotherapyp. 309
Immuno-Gene Therapy for Metastatic Prostate Cancerp. 337
Distilling the Past - Envisioning the Futurep. 355
Indexp. 399
Table of Contents provided by Ingram. All Rights Reserved.

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