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Summary

"The second edition of the treatment of Epilepsy is a vital contribution to the field. The book's primary focus is on the medical and surgical evaluation and treatment of the disease. Experts around the globe who have made seminal contributions to the treatment of epilepsy have contributed to the book, which preserves its flow and focus extremely well...This book is highly recommended and is a solid reference for anybody who is involved in the evaluation and medical care of patients with epilepsy." New England Journal of Medicine 352;7There is a wide variety of different types of epilepsy and seizures and a large array of available treatments suited to differing clinical situations. Consequently, the successful treatment of epilepsy is a complex process involving careful and rational analysis of a large number of variables and is rarely achieved. In recent years, there have been rapid advances both in medical and surgical treatments and and the complexity of treatment has increased still further. There remain important unresolved issues and controversies. Most of the existing large books on the subject either concentrate too much on the biology and phenomenology of epilepsy at the expense of therapy or else fail to balance the medical and surgical treatments available. This book aims to be the definitive textbook on medical and surgical treatment of epilepsy and to act as a clinical reference book with a strong practical bias.It will take the form of a detailed review and distillation of the literature rather than a presentation of individual research and will provide answers to the diversity of questions encountered in day to day clinical practice. In this way, the clinician will be guided through the difficult decision-making processes involved in the successful diagnosis and therapy.After a concise summary of the recent scientific developments in epileptology and discussion of the classification and diagnosis of epilepsy, the large medical will cover in detail the indications, clinical pharmacology, pharmacokinetics, toxicity and outcome of drug treatment. The surgical section will cover indications, patient selection, pre-surgical assessment, surgical technique, anaesthesia, complications and outcome.

Table of Contents

Contributors
Foreword
Preface to the Second Edition
Preface to the First Edition
The drug treatment of epilepsy between 1938-1955, with special reference to Epilepsia the Journal of the International League Against Epilepsy
Introduction
Definitions and classifications of epilepsy
Epidemiology and prognosis of epilepsy and its treatment
Sudden death in epilepsy
Aetiology of epilepsy
Differential diagnosis of epilepsy
Mechanisms of epileptogenesis
Mechanisms of drug resistence in epilespy
Antiepileptic drug discovery
Mechanisms of antiepileptic drug action
Drug interactions in epilepsy
Principles of Medical Treatment
General principles of medical treatment
Management of newly diagnosed epilepsy
Management of epilepsy in remission
Management of epilepsy in infants
Management of epilepsy in children
Management of epilepsy in the elderly person
Management of epilepsy in people with learning disability
Emergency treatment of seizures and status epilepticus
Treatment of epilepsy in general medical conditions
Treatment of psychiatric disorders in epilepsy
The ketogenic diet
Complementary and alternative treatments in epilepsy
Reproductive aspects of epilepsy treatment
Genetic counselling in epilepsy
Diagnosis and treatment of non-epileptic seizures
Drugs used in the Treatment of Epilepsy
The choice of drugs and approach to drug treatment in epilepsy
Acetazolamide
Carbamazepine
Clobazam
Clonazepam
Short-acting and other benzodiazepines
Ethosuximide
Felbamate
Fosphenytoin
Gabapentin
Lamotrigine
Levetiracetam
Oxcarbazepine
Phenobarbital, primidone and other barbiturates
Phenytoin
Piracetam
Pregabalin
Rufinamide
Tiagabine
Topiramate
Valproate
Vigabatrin
Zonisamide
Other drugs more rarely used in the treatment of epilepsy
Antiepileptic drugs used in clinical trials
Presurgical Evaluation of Epilepsy and Epilepsy Surgery
Introduction to epilepsy surgery and its Presurgical Assessment
Scalp EEG in presurgical evaluation of epilepsy
Invasive EEG in presurgical evaluation of epilepsy
MEG in presurgical evaluation of epilepsy
MRI in presurgical evaluation of epilepsy
PET and SPECT in presurgical evaluation of epilepsy
New physiological and radiological investigations in the presurgical evaluation of epilepsy
Psychological testing in presurgical evaluation of epilepsy
The role of psychiatric assessment in presurgical evaluation
Surgery of hippocampal sclerosis
Resective surgery of neoplastic lesions for epilepsy
Resective surgery of vascular and infective lesions for epilepsy
Surgery of cortical dysgenesis for epilepsy
Surgery of post-traumatic epilepsy
Paediatric epilepsy surgery
Hemispherectomy for epilepsy
Corpus callosum section for epilepsy
Multiple subpial transection for epilepsy
Awake operations for epilepsy
Stereotactic surgery for epilepsy
Complications of epilepsy surgery
Anaesthesia for epilepsy surgery
Vagal nerve stimulation
Future surgical approaches to epilepsy
Index
Table of Contents provided by Publisher. All Rights Reserved.

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