Molecular and Biochemical Toxicology
by Smart, Robert C.; Hodgson, ErnestEdition: 4th
Format: Hardcover
Pub. Date: 2008-08-18
Publisher(s): Wiley
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Summary
This book is an important resource for academic and industrial toxicologists in toxicology, chemistry, biochemistry, pharmacology. New chapters on the molecular topics of proteomics, toxicogenomics, metabolomics, bioinformatics, and pharmaco(toxico)genetics complement the updated coverage of biochemical toxicology.
Author Biography
Robert C. Smart, PhD, is a Professor in the Department of Environmental and Molecular Toxicology at North Carolina State University. Together with Dr. Hodgson, he coedited the previous edition of this book.
Ernest Hodgson, PhD, is the William Neal Reynolds Professor of Toxicology at North Carolina State University. He edited A Textbook of Modern Toxicology, Third Edition (Wiley) and is the Editor of the Journal of Biochemical and Molecular Toxicology.
Table of Contents
| Preface | |
| Contributors | |
| Molecular and Biochemical Toxicology: Definition and Scope | |
| Introduction | |
| Toxicology | |
| Biochemical Toxicology | |
| Cellular Toxicology | |
| Molecular Toxicology | |
| Proteomics, Metabolomics | |
| Conclusions.Suggested Reading | |
| Overview of Molecular Techniques in Toxicology: Genes and Transgenes | |
| Applicability of Molecular Techniques to Toxicology | |
| Overview of the Genetic Code and Flow of Genetic Information | |
| Molecular Cloning | |
| Southern and Northern Blot Analyses | |
| Polymerase Chain Reaction (PCR | |
| Some Methods to Evaluate Gene Expression and Regulation | |
| Methods to Evaluate Gene function | |
| Toxicogenomics | |
| Introduction | |
| A Primer of Genomics | |
| Tools and Approaches | |
| Genomes | |
| Functional Genomics | |
| Conclusions | |
| Proteomics | |
| Introduction to Proteomics | |
| Properties of Proteins | |
| Fields of Proteomic Research | |
| Mass Spectrometers and Protein Identification | |
| Proteomic Platforms | |
| Proteomes and Subproteomes: Expectations and Reality | |
| Summary | |
| Metabolomics | |
| Introduction | |
| Methods | |
| Diagnostics and Functional Genomics | |
| Metabolomics and Toxicology | |
| Bioinformatics | |
| Introduction | |
| Obtaining the Genbank Record of a Known Gene | |
| Sequence Comparison | |
| Database Searching With BLAST | |
| Extensions to Multiple Sequences | |
| Genetic Mapping | |
| Conclusion | |
| Immunochemical Techniques in Toxicology | |
| Introduction | |
| Definitions | |
| Immunogens and Antigens | |
| Polyclonal Antibodies | |
| Monoclonal Antibodies | |
| Immunoassays | |
| Conclusions | |
| Cellular Techniques | |
| Introduction | |
| Cellular Studies in Intact Tissue | |
| Studies with Dispersed, Isolated Cells | |
| Monolayer Cell Culture | |
| Observation of Cultured Cells | |
| Indicators of Toxicity | |
| Artifacts and Confounders | |
| Replacement of Animal Testing with Cell Culture Models | |
| Conclusions | |
| Structure, Mechanism and Regulation of Cytochromes P450 | |
| Introduction | |
| Complexity of the Cytochrome P450 Gene Superfamily | |
| Cytochrome P450 Structure | |
| Mechanisms of P450 Catalysis | |
| Cytochrome P450 Regulation | |
| Transgenic Animal Models | |
| Reactive Oxygen Species | |
| Posttranslation Modification of P450s | |
| Summary | |
| Phase I Metabolism of Toxicants and Metabolic Interactions | |
| Introduction | |
| Microsomal Monooxygenations: General Background | |
| Nonmicrosomal Oxidations | |
| Cooxidation by Prostaglandin Synthetase | |
| Reduction Reactions | |
| Hydrolysis | |
| Epoxide Hydration | |
| DDT Dehydrochlorinase | |
| Interactions Involving Xenobiotic-Metabolizing Enzymes | |
| Phase I Pharmacogenetics | |
| Introduction | |
| Polymorphisms in CYP Isoforms | |
| Polymorphisms in Alcohol Dehydrogenase | |
| Polymorphisms in Aldehyde Dehydrogenase | |
| Polymorphisms in Flavin-Containing Monooxygenases | |
| Polymorphisms in Epoxide Hydrolase | |
| Polymorphisms in Serum Cholinesterase | |
| Table of Contents provided by Publisher. All Rights Reserved. |
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