Organic Synthesis The Disconnection Approach
by Warren, Stuart; Wyatt, PaulEdition: 2nd
Format: Hardcover
Pub. Date: 2008-12-31
Publisher(s): Wiley
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Summary
"This book introduces this important technique, to help students to design their own organic syntheses. This edition has been revised and updated with a modern look. Recent examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel. This book provides a full course in retrosynthetic analysis for chemistry and biochemistry students and a refresher for organic chemists working in industry and academia."--BOOK JACKET.
Author Biography
Dr Stuart Warren, Department of Chemistry, University of Cambridge, UK
Dr Warren is the author of the bestselling textbooks Organic Synthesis: The Disconnection Approach (Wiley), Organic Synthesis: Strategy and Control (Wiley) and Organic Chemistry (OUP).
Dr Paul Wyatt, School of Chemistry, University of Bristol, UK
Dr Wyatt is Director of Undergraduate Studies for the School of Chemistry at Bristol University and also Director of BRISTOL ChemLabS - a HEFCE Centre for Excellence in Teaching & Learning. He is co-author, with Warren, of Organic Synthesis: Strategy and Control.
Table of Contents
| Preface | p. ix |
| General References | p. xi |
| The Disconnection Approach | p. 1 |
| Basic Principles: Synthons and Reagents Synthesis of Aromatic Compounds | p. 7 |
| Strategy I: The Order of Events | p. 17 |
| One-Group C-X Disconnections | p. 23 |
| Strategy II: Chemoselectivity | p. 29 |
| Two-Group C-X Disconnections | p. 35 |
| Strategy III: Reversal of Polarity, Cyclisations, Summary of Strategy | p. 45 |
| Amine Synthesis | p. 53 |
| Strategy IV: Protecting Groups | p. 61 |
| One Group C-C Disconnections I: Alcohols | p. 69 |
| General Strategy A: Choosing a Disconnection | p. 77 |
| Strategy V: Stereoselectivity A | p. 83 |
| One Group C-C Disconnections II: Carbonyl Compounds | p. 93 |
| Strategy VI: Regioselectivity | p. 101 |
| Alkene Synthesis | p. 107 |
| Strategy VII: Use of Acetylenes (Alkynes) | p. 115 |
| Two-Group C-C Disconnections I: Diels-Alder Reactions | p. 121 |
| Strategy VIII: Introduction to Carbonyl Condensations | p. 129 |
| Two-Group C-C Disconnections II: 1,3-Difunctionalised Compounds | p. 133 |
| Strategy IX: Control in Carbonyl Condensations | p. 139 |
| Two-Group C-C Disconnections III: 1,5-Difunctionalised Compounds Conjugate (Michael) Addition and Robinson Annelation | p. 151 |
| Strategy X: Aliphatic Nitro Compounds in Synthesis | p. 161 |
| Two-Group Disconnections IV: 1,2-Difunctionalised Compounds | p. 167 |
| Strategy XI: Radical Reactions in Synthesis | p. 177 |
| Two-Group Disconnections V: 1,4-Difunctionalised Compounds | p. 185 |
| Strategy XII: Reconnection | p. 193 |
| Two-Group C-C Disconnections VI: 1,6-diCarbonyl Compounds | p. 199 |
| General Strategy B: Strategy of Carbonyl Disconnections | p. 207 |
| Strategy XIII: Introduction to Ring Synthesis: Saturated Heterocycles | p. 217 |
| Three-Membered Rings | p. 229 |
| Strategy XIV: Rearrangements in Synthesis | p. 237 |
| Four-Membered Rings: Photochemistry in Synthesis | p. 245 |
| Strategy XV: The Use of Ketenes in Synthesis | p. 251 |
| Five-Membered Rings | p. 255 |
| Strategy XVI: Pericyclic Reactions in Synthesis: Special Methods for Five-Membered Rings | p. 261 |
| Six-Membered Rings | p. 269 |
| General Strategy C: Strategy of Ring Synthesis | p. 279 |
| Strategy XVII: Stereoselectivity B | p. 289 |
| Aromatic Heterocycles | p. 301 |
| General Strategy D: Advanced Strategy | p. 313 |
| Index | p. 325 |
| Table of Contents provided by Ingram. All Rights Reserved. |
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