Practical Organic Synthesis A Student's Guide

by ; ; ;
Edition: 1st
Format: Hardcover
Pub. Date: 2006-06-16
Publisher(s): WILEY
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Summary

Success in an experimental science such as chemistry depends on good laboratory practice, a knowledge of basic techniques, and the intelligent and careful handling of chemicals.Practical Organic Synthesis is a concise, useful guide to good laboratory practice in the organic chemistry lab with hints and tips on successful organic synthesis. Topics covered include: safety in the laboratory environmentally responsible handling of chemicals and solvents crystallisation distillation chromatographic methods extraction and work-up structure determination by spectroscopic methods searching the chemical literature laboratory notebooks writing a report hints on the synthesis of organic compounds disposal and destruction of dangerous materials drying and purifying solventsPractical Organic Synthesis is based on a successful course in basic organic chemistry laboratory practice which has run for several years at the ETH, Zurich and the University of Berne, and its course book Grundoperationen, now in its sixth edition.Condensing over 30 years of the authors' organic laboratory teaching experience into one easy-to-read volume, Practical Organic Synthesis is an essential guide for those new to the organic chemistry laboratory, and a handy benchtop guide for practising organic chemists.

Author Biography

Reinhart Keese is the author of Practical Organic Synthesis: A Student's Guide, published by Wiley.

Martin P. Brändle is the author of Practical Organic Synthesis: A Student's Guide, published by Wiley.

Trevor P. Toube is the author of Practical Organic Synthesis: A Student's Guide, published by Wiley.

Table of Contents

Preface vii
CHAPTER 1 Accident Prevention and First Aid 1(8)
1.1 Safety
1(3)
1.2 Avoiding Accidents
4(5)
CHAPTER 2 Environmentally Responsible Handling of Chemicals and Solvents 9(10)
2.1 Dangerous Materials: Poisons, Laws, Regulations and Classes
10(1)
2.2 EU Poison Regulations
10(3)
2.3 Concentration Limits
13(1)
2.4 Chemical Carcinogens
14(5)
CHAPTER 3 Crystallisation 19(8)
CHAPTER 4 Distillation 27(10)
4.1 Some Theoretical Considerations
28(2)
4.2 Distillation in Practice
30(7)
CHAPTER 5 Chromatographic Methods 37(18)
5.1 Basic Principles
37(3)
5.2 Analytical and Preparative Thin—Layer Chromatography
40(2)
5.3 Column Chromatography
42(7)
5.4 Rapid Column Chromatography
49(2)
5.5 HPLC
51(4)
CHAPTER 6 Extraction and Isolation 55(8)
6.1 Separation of Mixtures According to Acidity
56(7)
CHAPTER 7 Structure Determination Using Spectroscopic Methods 63(10)
7.1 Infrared Spectroscopy (IR)
63(1)
7.2 Mass Spectrometry (MS)
64(1)
7.3 Nuclear Magnetic Resonance Spectroscopy (NMR)
64(1)
7.4 Ultraviolet and Visible Spectroscopy (UV/VIS)
64(9)
CHAPTER 8 Searching the Chemical Literature 73(38)
8.1 The Information Mountain
73(1)
8.2 Strategy
74(1)
8.3 Databases
74(31)
8.4 Reviews
105(2)
8.5 Monographs, Reference Works and Handbooks
107(1)
8.6 Data Collections
108(3)
CHAPTER 9 Laboratory Notebooks 111(4)
CHAPTER 10 Writing a Report 115(4)
CHAPTER 11 Example of a Laboratory Report 119(4)
CHAPTER 12 Hints on the Synthesis of Organic Compounds 123(24)
12.1 The Route to Success
123(6)
12.2 Some Tips on Handling Water- and Air-Sensitive Substances
129(7)
12.3 Hints on Working at Low Temperatures
136(2)
12.4 Hints on the Synthesis and Analysis of Chiral Compounds
138(2)
12.5 Hints on the Synthesis of Isotopically Labelled Compounds
140(7)
CHAPTER 13 Disposal and Destruction of Dangerous Materials 147(12)
13.1 Classification of Waste Material
148(1)
13.2 Environmentally Acceptable Substances for Treating Dangerous Materials in the Laboratory
149(1)
13.3 Special Instructions for the Destruction of the Main Classes of Dangerous Substances
149(6)
13.4 Deactivation of Unknown Laboratory Chemicals
155(1)
13.5 Waste Disposal
156(3)
CHAPTER 14 Purification and Drying of Solvents 159(26)
14.1 Some Drying Agents
160(5)
14.2 Solvents
165(20)
CHAPTER 15 EU R and S Phrases 185(8)
15.1 R Phrases: Indication of Particular Risks
185(2)
15.2 Combinations of R Numbers
187(2)
15.3 S Phrases: Indication of Safety Precautions
189(2)
15.4 Combinations of S Numbers
191(2)
Index 193

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